Solubility Enhancement of Efavirenz Hydrochloride by Hot Melt Technique
نویسندگان
چکیده
منابع مشابه
Dissolution and Bioavailability Enhancement of Efavirenz by Hot Melt Extrusion Technique
The aim of this study is to improve dissolution and bioavailability of poorly water soluble Efavirenz (Efv), a potent and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Its effectiveness can be attributed to its long half-life (t1/2) of 52–76 h after single dose. Formulation of poorly water soluble drug for oral delivery is one of the biggest challenges. Amongst the availabl...
متن کاملHot-Melt Extrusion Technique: A Review
Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...
متن کاملHot Melt Extrusion Technique
Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug ...
متن کاملEnhancement of solubility and dissolution rate of Fenofibrate by melt granulation technique
This work describes a melt granulation technique to improve the solubility and dissolution characteristics of a poorly water-soluble drug Fenofibrate (FNO). Melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated by a meltable polymers and surfactants. The advantage of this technique compared to a conventional granulation is that no water or organic ...
متن کاملHot-Melt Extrusion Technique: A Review
Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Current Pharma Research
سال: 2011
ISSN: 2230-7834,2230-7842
DOI: 10.33786/jcpr.2011.v01i04.006